What if Parkinson's disease did not develop only in the brain? A disease that has been named neurodegenerative, one of its origin could be in the gastrointestinal tract. In a study published in Science Translational Medicine, 1.5 million people in Sweden found a link between the removal of oral cavities and the onset of Parkinson's disease.
For 1.7 million people, the study found that people who had had the attachment removed were up to 20% less likely to develop Parkinson's disease. On the other hand, people who have had conjunctivitis and have had delayed onset of the disease for an average of four years.
In addition, the earlier the disease associated proteins have been found in Appendix and in other parts of the digestive tract, thereby increasing the existing evidence that connect the brain bowel disease.
The attachment is not useless
The appendix contains a protein, an alpha synaptone, which is known to accumulate in the brain of Parkinson's disease patients. "Alpha-synuclein is a protein that does not want to remain immobile, can migrate from neuronal to neurons if it comes to the brain, it can germinate and spread, and has neurotoxic effects that can ultimately lead to Parkinson's disease", describes Viviane Labrie, one of the researchers.
Although its reputation is largely unnecessary, the attachment plays a very important role in the immune system, regulates the intestinal bacterial composition and now, as this study shows, the appearance of Parkinson's disease.
Be careful, but this research does not recommend removing the attachment, far from it. "We do not say that if you have ablation, you do not have Parkinson's disease"warns the scientist. At present, no causal relationship has been established. As with this type of study, other factors that are ignored can explain the difference that has been removed and the other.