One study suggests that the ability of the irregular bowel again with new neurons and eliminate the dead could result in Parkinson's disease.
Recently, it is certain that the nervous system extends to the gastrointestinal tract. However, the relationship between this enteric nervous system and the brain is not yet clear. I understand it as a research team in the United States. He has done research in mice and has found that nerve cells forming neurons are almost completely replaced every other week.
In addition, the results of the study are presented in San Diego at the annual Society neuroscience, refer to the imbalance in the intestine's ability to re-new neurons and the removal of dead can lead to Parkinson's disease.
advisable: A poor diet is associated with higher cancer risks, the expert says
Neurons go, neurons come
"The problems of balancing cells, not the neurons themselves, can cause complications and gastrointestinal disorders," he said at a meeting, Subhash Kulkarni from Johns Hopkins University, Maryland.
He and his team found that neurons in the mouse intestinal lining of the gut are killed constant and relatively high speed. Almost one-third of the mouse intestine nerve cells lost after seven days. However, the dead neurons did not accumulate, removed from the macrophage, bacterial and viral cancer cells.
The researchers found that the intestine had to produce new cells to replace neurons that were dead and wiped out. They found that there are stem cells in the intestine that grow very fast. In mice after two weeks, 88% of neurons are located They formed again between the two muscle layers of the stomach. In other words, cell turnover is high, but the number of neurons remains the same.
See also: Reducing the attachment reduces the risk of Parkinson's disease by up to 25%
Relationship with Parkinson's disease
Not only is Kulkarni suspect the accumulation of alpha-synuclein, a protein whose accumulation may inhibit nerve signals in the brain of Parkinson's disease, it may be a consequence of the nerve cell turnover.
"If something goes wrong with the cleansing mechanisms or if we have interferences between the continuous new neurons and the ongoing cleansing, there will be accumulation," he says. "And the more debris accumulates, the higher alpha-synuclein groups can come," he adds.
To support the hypothesis, Kulkarni says his team has preliminary information on a new study. When changing the number or rate of the presence of the macrophages present at the intestine of the neurons, scientists manipulate cell life / death rate. When they do, they see the initials of the accumulation of proteins that have led to Parkinson's disease, Kulkarni says.
Also read: These are five healthy ways to prolong life for over a decade
However, all experts do not entirely agree with Kulkarni's proposal. "I do not doubt his findings, but I do not think that's the whole story," New Scientist told Ruth G. Perez of Parkinson's at Texas Tech University in El Paso. "If nerve cell sales are so fast, why will we continue to see protein accumulation in Parkinson's patients?"
Relationship between gastrointestinal tract and Parkinson's disease they begin to understand each other more clearly. Less than a week ago, experts from Van Andel's research institute in Michigan, USA, found that the aforementioned neurodegenerative disease may be from a joint.
This news was originally published in N + 1, which adds scientific information