Because of the FLU vaccine shortage, thousands of people over the age of 65 were unable to get points.
GPs and chemists have repeatedly turned the patients away.
And while fresh supplies should be available next week, there are fears that many older people do not bother to return.
Deficiencies have been recorded in many areas such as Bristol, Kent, Devon, West Sussex, Essex, Derbyshire, Middlesbrough and Liverpool.
Sources told Daily Mail that the latest vaccine, called Fluad, is more effective, but can not be ordered later than usual. Some general practitioners argue that there are also delays in getting official advice on how to use it.
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John Kell, of the Patient Association, said: "This poses a very worrying risk to patient safety and may cause NHS services to continue under pressure."
NHS published by EHK shows that 45.2 percent of people over the age of 65 have received the vaccine so far compared to 61.9 percent over the same period last year.
The NHS in England says that the jab "will be available to everyone in time when the flu season begins normally in December".
Bristol's pharmacist John Billing said he had translated up to 15 patients a day.
He said, "It's coming to the point where some patients say" well, I'll forget it this year. ""