Friday , March 5 2021

Scientists develop biomaterials capable of combating Alzheimer's and Parkinson's disease

The investigator group achieved functional recovery of the mice after stroke after implantation of stem cells encased in hydrogel produced by silk fibroblasts.

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Alberto Iglesias Fraga

Mexico City, November 10 (TICbeat / SinEmbargo) .- Imagine the following: some scientists implanted encapsulated stem cells a harmless biomaterials and fully biocompatible with which they get the functional recovery of people suffering from a stroke, nerve repair damaged and avoid damaging the damage.

It sounds like a science fiction, but nothing is far from reality. The UPM research team, in collaboration with the Complutense University of Madrid (UCM), the Cajal Institute and the San Carlos Clinical Hospital, has carefully developed that mice with stroke after implantation encapsulated stem cells hydrogels silkkifibriini.

A wide range of neurological diseases produce permanent physical and cognitive disabilities. Our nervous system has very limited ability to recover after injury, such as in the brain and brain injury and neurodegenerative diseases such as Alzheimer's or Parkinson's with a progressive deterioration of the brain's activity. Stem cell therapy has been a huge strategic leap in treating these diseases because of its therapeutic potential to protect and repair damaged brain. However, the transmission of stem cells is not without difficulty, including its reduced survival in the brain after transplantation, which is an important barrier to achieving maximum therapeutic efficacy.

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In trying to overcome this obstacle, these Spanish scientists have developed a new biotechnology strategy to remedy damaged brain tissue. For this purpose, they used a brain-specific infection to mice, where stem cells of mesenchymal origin were implanted as non-encapsulated and fully biocompatible biomaterial: silk fibrin. After treatment, the mice had a significant improvement in sensory and motor abilities that had deeply changed after the stroke. In addition, by using electrophysiological methods, researchers demonstrated that this functional improvement involved brain reordering phenomena in areas adjacent to the disease zone. A significant part of this study was that silk fibroin significantly increased the survival of implanted stem cells in the brain, thus preventing further damage from postponing stroke in animals.

According to CTB UPM researcher Daniel González Nieton, "these results open up a hopeful pathway to neurological disorders by means of a new type of advanced therapy based on the use of silk fibroin as a tool for delivering cells, thereby increasing the therapeutic performance and functional improvement of patients."


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